Life Science & Health

Whether used to treat bone fractures, replace teeth or act as pacemakers, metallic implants have become an irreplaceable part of modern medicine. They must remain stable while integrating with surrounding tissue. A new avenue being explored in the field of biological implants is designing titanium-magnesium hybrid implants that combine the advantages of both materials to create superior implants. Titanium is used for its high strength, while the magnesium component dissolves over time and helps stimulate bone growth. Such materials have the potential to revolutionise metallic implants.

A research group from Lund has investigated the crystalline proteins of the eye lens at the MLZ. Using neutrons, they showed that macroscopic properties can be predicted surprisingly well using simple mixing rules. The results provide new insights into age-related changes in the lens and open up perspectives for research into diseases such as Alzheimer’s or cataracts.

A newly developed prototype at FRM II enables complex microbeam therapy for the first time, allowing it to be performed at a distance of only one and a half meters. Until now, this new form of radiation therapy, which enables better tumor control and fewer side effects than conventional methods, could only be performed using giant particle accelerators and was therefore not a realistic option for clinical use. The line-focus X-ray tube, the world’s first prototype of which was built at FRM II, could bring micro-radiation therapy into clinical application for the first time.

In an effort to provide more targeted therapies for cancer patients, the Technical University of Munich (TUM), the TUM University Hospital, and ITM Isotope Technologies Munich SE have signed a research framework agreement. Through this partnership, the institutions aim to enhance their collaboration and involvement of the FRM II research reactor in the fields of nuclear medicine, radiopharmacy, and medical isotope technology.

Proteins are long-chain molecules essential for all biochemical processes in our body. How they move exactly in the densely packed cell interior has yet to be clarified. A Spanish research team has investigated at the MLZ how the dynamics of mimetic model polymer nanoparticles change depending on their environment.

Up to three percent of people with diabetes have an allergic reaction to insulin. A team at Forschungszentrum Jülich has now investigated a method that could be used to deliver the active ingredient into the body in a masked form – in the form of tiny nanoparticles. The insulin is only released in the target organ when the pH value deviates from the slightly alkaline environment in the blood. The molecular transport system could also serve as a platform to release other drugs in the body precisely at the target site.

The cyanobacterium Prochlorococcus is the smallest and most abundant photosynthetic organism in the world. It has found a particularly efficient way to absorb and store vital iron. Using neutron, X-ray, and synchrotron experiments, an international team of researchers has visualized the molecular mechanism for the first time.

Milk alternatives made from sugar beet leaves – this is the vision of a Jülich research team. They have examined milk proteins and other components in cheese, yoghurt, cow’s milk and oat milk using X-rays and neutrons to find out what the structure of the products and individual components must be like in order for them to be stable, appealing and nutritious.